Population genetics of translational robustness

Details Population genetics of translational robustness Population genetics of translational robustness

2005-09-24

arxiv.org/abs/q-bio/0509031v2

Biology

Quantitative Biology

Populations and Evolution

32 pages, 4 figures, Genetics in press

Scientific paper

Recent work has shown that expression level is the main predictor of a gene’s evolutionary rate, and that more highly expressed genes evolve slower. A possible explanation for this observation is selection for proteins which fold properly despite mistranslation, in short selection for translational robustness. Translational robustness leads to the somewhat paradoxical prediction that highly expressed genes are extremely tolerant to missense substitutions but nevertheless evolve very slowly. Here, we study a simple theoretical model of translational robustness that allows us to gain analytic insight into how this paradoxical behavior arises.

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