Mathematics – Logic
Scientific paper
Aug 1971
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1971slsci...3...54b&link_type=abstract
Space Life Sciences, Volume 3, Issue 1, pp.54-62
Mathematics
Logic
3
Scientific paper
The adenylates of an amino acid mixture were polymerized in aqueous solution as a model to study amino acid sequence control at an intermediate level above prebiological conditions yet in the absence of highly evolved cellular constraints. As a first step, the homogeneous polymerization was investigated in detail. A mixture of sixteen free amino acids, including C-14 label, was converted to the adenylates using a low 10∶1 molar excess of condensing agent over free amino acid. The adenylates were polymerized in alkaline buffer, or hydrolyzed in acid, and directly analyzed on Sephadex and Dowex columns. A comparison of the polymerized and hydrolyzed samples showed that condensed products were formed during the adenylate synthesis stage. The yield of distinctly polymerized material was small (<5%) and was found to trail the elution of free amino acids on Sephadex. This material may be separated into a small number of distinct bands by electrophoresis, and has an amino acid composition that does not reflect that of the starting mixture.
Banda P. W.
Ponnamperuma Cyril
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