Phase Transition in Reconstituted Chromatin

Details Phase Transition in Reconstituted Chromatin Phase Transition in Reconstituted Chromatin

2004-07-07

arxiv.org/abs/q-bio/0407011v3

Europhysics Letters, Vol. 69, Iss. 6, pp. 1024-1030 (2005)

Biology

Quantitative Biology

Subcellular Processes

16 pages, 3 figures

Scientific paper

By observing reconstituted chromatin by fluorescence microscopy (FM) and atomic force microscopy (AFM), we found that the density of nucleosomes exhibits a bimodal profile, i.e., there is a large transition between the dense and dispersed states in reconstituted chromatin. Based on an analysis of the spatial distribution of nucleosome cores, we deduced an effective thermodynamic potential as a function of the nucleosome-nucleosome distance. This enabled us to interpret the folding transition of chromatin in terms of a first-order phase transition. This mechanism for the condensation of chromatin is discussed in terms of its biological significance.

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