Pattern Formation of Glioma Cells: Effects of Adhesion

Details Pattern Formation of Glioma Cells: Effects of Adhesion Pattern Formation of Glioma Cells: Effects of Adhesion

2008-07-19

arxiv.org/abs/0807.3126v2

EPL (Europhysics Letters) 88, 28006 (2009)

Biology

Quantitative Biology

Cell Behavior

6 pages, 6 figures

Scientific paper

10.1209/0295-5075/88/28006

We investigate clustering of malignant glioma cells. \emph{In vitro} experiments in collagen gels identified a cell line that formed clusters in a region of low cell density, whereas a very similar cell line (which lacks an important mutation) did not cluster significantly. We hypothesize that the mutation affects the strength of cell-cell adhesion. We investigate this effect in a new experiment, which follows the clustering dynamics of glioma cells on a surface. We interpret our results in terms of a stochastic model and identify two mechanisms of clustering. First, there is a critical value of the strength of adhesion; above the threshold, large clusters grow from a homogeneous suspension of cells; below it, the system remains homogeneous, similarly to the ordinary phase separation. Second, when cells form a cluster, we have evidence that they increase their proliferation rate. We have successfully reproduced the experimental findings and found that both mechanisms are crucial for cluster formation and growth.

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