Biology – Quantitative Biology – Quantitative Methods
Scientific paper
2006-06-14
Proceedings of 28th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE (2006), pages 553
Biology
Quantitative Biology
Quantitative Methods
submitted to IEEE/EMBS Conference'06
Scientific paper
10.1109/IEMBS.2006.260828
When the same set of genes appear in two top ranking gene lists in two different studies, it is often of interest to estimate the probability for this being a chance event. This overlapping probability is well known to follow the hypergeometric distribution. Usually, the lengths of top-ranking gene lists are assumed to be fixed, by using a pre-set criterion on, e.g., $p$-value for the t-test. We investigate how overlapping probability changes with the gene selection criterion, or simply, with the length of the top-ranking gene lists. It is concluded that overlapping probability is indeed a function of the gene list length, and its statistical significance should be quoted in the context of gene selection criterion.
Batliwalla Franak
Fury Wen
Gregersen Peter K.
Li Wentian
No associations
LandOfFree
Overlapping Probabilities of Top Ranking Gene Lists, Hypergeometric Distribution, and Stringency of Gene Selection Criterion does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Overlapping Probabilities of Top Ranking Gene Lists, Hypergeometric Distribution, and Stringency of Gene Selection Criterion, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Overlapping Probabilities of Top Ranking Gene Lists, Hypergeometric Distribution, and Stringency of Gene Selection Criterion will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-607035