Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

Details Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

2008-03-31

arxiv.org/abs/0803.4415v2

Physical Review Letters 102, 6 (2009) 068104

Biology

Quantitative Biology

Quantitative Methods

Scientific paper

10.1103/PhysRevLett.102.068104

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator.

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