Origins of Life and the RNA World: Evolution of RNA-Replicase Recognition

Details Origins of Life and the RNA World: Evolution of RNA-Replicase Recognition Origins of Life and the RNA World: Evolution of RNA-Replicase Recognition

Jun 2004

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2004iaus..213..321g&link_type=abstract

Bioastronomy 2002: Life Among the Stars, Proceedings of IAU Symposium #213. Edited by R. Norris, and F. Stootman. San Francisco:

Astronomy and Astrophysics

Astronomy

Scientific paper

Central to understanding the origin of life is the elucidation of the first replication mechanism. The RNA World hypothesis suggests that the first self-replicating molecules were RNAs and that DNA later superceded RNA as the genetic material. RNA viruses were not subjected to the same evolutionary pressures as cellular organisms; consequently, they likely possess remnants of earlier replication strategies. Our laboratory investigates how members of the RNA virus family Bromoviridae can have structurally distinct 3' end tags yet are specifically recognized by conserved replication enzymes. This work addresses the idea that 3' tRNA tails were functionally replaced in some viruses by an RNA-protein complex. These viruses may serve as a timeline for the transition from the RNA world to DNA and protein based life.

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