Optimization Aspects of Carcinogenesis

Details Optimization Aspects of Carcinogenesis Optimization Aspects of Carcinogenesis

2009-07-12

arxiv.org/abs/0907.2004v3

Biology

Quantitative Biology

Populations and Evolution

Scientific paper

10.1016/j.mehy.2009.10.019

Any process in which competing solutions replicate with errors and numbers of their copies depend on their respective fitnesses is the evolutionary optimization process. As during carcinogenesis mutated genomes replicate according to their respective qualities, carcinogenesis obviously qualifies as the evolutionary optimization process and conforms to common mathematical basis. The optimization view accents statistical nature of carcinogenesis proposing that during it the crucial role is actually played by the allocation of trials. Optimal allocation of trials requires reliable schemas' fitnesses estimations which necessitate appropriate, fitness landscape dependent, statistics of population. In the spirit of the applied conceptual framework, features which are known to decrease efficiency of any evolutionary optimization procedure (or inhibit it completely) are anticipated as "therapies" and reviewed. Strict adherence to the evolutionary optimization framework leads us to some counterintuitive implications which are, however, in agreement with recent experimental findings, such as sometimes observed more aggressive and malignant growth of therapy surviving cancer cells.

Affiliated with

Also associated with

No associations

Rating

Optimization Aspects of Carcinogenesis does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Optimization Aspects of Carcinogenesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optimization Aspects of Carcinogenesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-593348