Optimal designs for dose-finding experiments in toxicity studies

Details Optimal designs for dose-finding experiments in toxicity studies Optimal designs for dose-finding experiments in toxicity studies

2009-02-09

arxiv.org/abs/0902.1426v1

Bernoulli 2009, Vol. 15, No. 1, 124-145

Statistics

Methodology

Published in at http://dx.doi.org/10.3150/08-BEJ152 the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statisti

Scientific paper

10.3150/08-BEJ152

We construct optimal designs for estimating fetal malformation rate, prenatal death rate and an overall toxicity index in a toxicology study under a broad range of model assumptions. We use Weibull distributions to model these rates and assume that the number of implants depend on the dose level. We study properties of the optimal designs when the intra-litter correlation coefficient depends on the dose levels in different ways. Locally optimal designs are found, along with robustified versions of the designs that are less sensitive to misspecification in the initial values of the model parameters. We also report efficiencies of commonly used designs in toxicological experiments and efficiencies of the proposed optimal designs when the true rates have non-Weibull distributions. Optimal design strategies for finding multiple-objective designs in toxicology studies are outlined as well.

Affiliated with

Also associated with

No associations

Rating

Optimal designs for dose-finding experiments in toxicity studies does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Optimal designs for dose-finding experiments in toxicity studies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optimal designs for dose-finding experiments in toxicity studies will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-176485