Biology – Quantitative Biology – Genomics
Scientific paper
2009-10-02
Biology
Quantitative Biology
Genomics
Scientific paper
The presence of clusters of rare codons is known to negatively impact the
efficiency and accuracy of protein production. In this paper, we demonstrate a
statistical method of identifying such clusters in the coding sequence of a
gene. Using E. coli as our model organism, we show that genes having denser
clusters tend to have lower protein yields.
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