On the clustering of rare codons and its effect on translation

Biology – Quantitative Biology – Genomics

Scientific paper

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Scientific paper

The presence of clusters of rare codons is known to negatively impact the
efficiency and accuracy of protein production. In this paper, we demonstrate a
statistical method of identifying such clusters in the coding sequence of a
gene. Using E. coli as our model organism, we show that genes having denser
clusters tend to have lower protein yields.

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