On Myosin II dynamics in the presence of external loads

Details On Myosin II dynamics in the presence of external loads On Myosin II dynamics in the presence of external loads

2005-04-18

arxiv.org/abs/q-bio/0504023v1

Biology

Quantitative Biology

Subcellular Processes

6 figures, 8 tables, to appear on Biosystems

Scientific paper

We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by some of us in a previous paper. In this new model a Brownian motion harnessing thermal energy is assumed to co-exist with the deterministic swing of the lever-arm, to yield an excellent fit of the set of data obtained by some of us on the sliding of Myosin II heads on immobilized actin filaments under various load conditions. Our theoretical arguments are complemented by accurate numerical simulations, and the robustness of the model is tested via different choices of parameters and potential profiles.

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