On a generalized false discovery rate

Details On a generalized false discovery rate On a generalized false discovery rate

2009-06-17

arxiv.org/abs/0906.3091v1

Annals of Statistics 2009, Vol. 37, No. 3, 1545-1565

Mathematics

Statistics Theory

Published in at http://dx.doi.org/10.1214/08-AOS617 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of

Scientific paper

10.1214/08-AOS617

The concept of $k$-FWER has received much attention lately as an appropriate error rate for multiple testing when one seeks to control at least $k$ false rejections, for some fixed $k\ge 1$. A less conservative notion, the $k$-FDR, has been introduced very recently by Sarkar [Ann. Statist. 34 (2006) 394--415], generalizing the false discovery rate of Benjamini and Hochberg [J. Roy. Statist. Soc. Ser. B 57 (1995) 289--300]. In this article, we bring newer insight to the $k$-FDR considering a mixture model involving independent $p$-values before motivating the developments of some new procedures that control it. We prove the $k$-FDR control of the proposed methods under a slightly weaker condition than in the mixture model. We provide numerical evidence of the proposed methods' superior power performance over some $k$-FWER and $k$-FDR methods. Finally, we apply our methods to a real data set.

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