Computer Science
Scientific paper
Dec 2007
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007oleb...37..495z&link_type=abstract
Origins of Life and Evolution of Biospheres, Volume 37, Issue 6, pp.495-505
Computer Science
1
Peptide Synthesis, Thioamino Acids, Lipid Surface Catalysis, Bilayer Permeability
Scientific paper
For cellular life to begin on the early Earth, a permeation mechanism would be required to allow polar solutes to enter a membrane-bounded compartment. A second process - internal polymerization of peptides from amino acid - would also be an essential step toward the first compartmented metabolic pathways leading to biosynthesis. Here we report a study of amino acid permeation into lipid vesicles, in which thioglutamic acid penetrated lipid bilayer membranes at rates sufficient to support internal polymerization reactions. We also investigated spontaneous non-enzymatic polymerization reactions of thioglutamic acid to form oligopeptides. We found that oligomers up to 11mers are produced in the reaction mixture, and conclude that certain lipid surfaces can act as catalysts in promoting an oligomerization reaction. These observations are pertinent to understanding processes by which peptide bond synthesis could take place in primitive cellular life on the early Earth.
Deamer David
Maurel Marie-Christine
Rajamani Sriram
Zepik H. H.
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