Oligomerization of deoxynucleoside-bisphosphate dimers: Template and linkage specificity

Computer Science

Scientific paper

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Scientific paper

Evidence is presented that a poly(U) template selectively favors the
oligomerization of the activated, 3' 5' pyrophosphate-linked dimer
pdAppdAp, in comparison with the 3' 3' and 5' 5' linked dimers. In the
absence of poly(U), the 5' 5'linked dimer is the most reactive, and
chains are formed which are more than 60 monomer units in length.

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