Numerical Solution of a Complete Formulation of Flow in a Perfusion Bone-Tissue Bioreactor Using Lattice Boltzmann Equation Method

Biology – Quantitative Biology – Quantitative Methods

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

9 pages, 3 figures

Scientific paper

We report the key findings from numerical solutions of a model of transport within an established perfusion bioreactor design. The model includes a complete formulation of transport with fully coupled convection-diffusion and scaffold cell attachment. It also includes the experimentally determined internal (Poly-L-Lactic Acid (PLLA)) scaffold boundary, together with the external vessel and flow-port boundaries. Our findings, obtained using parallel lattice Boltzmann equation method, relate to (i) whole-device, steady-state flow and species distribution and (ii) the properties of the scaffold. In particular the results identify which elements of the problem may be addressed by coarse grained methods such as the Darcy approximation and those which require a more complete description. The work demonstrates that appropriate numerical modelling will make a key contribution to the design and development of large scale bioreactors.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Numerical Solution of a Complete Formulation of Flow in a Perfusion Bone-Tissue Bioreactor Using Lattice Boltzmann Equation Method does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Numerical Solution of a Complete Formulation of Flow in a Perfusion Bone-Tissue Bioreactor Using Lattice Boltzmann Equation Method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Numerical Solution of a Complete Formulation of Flow in a Perfusion Bone-Tissue Bioreactor Using Lattice Boltzmann Equation Method will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-160506

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.