Nucleic acid-like structures II. Polynucleotide analogues as possible primitive precursors of nucleic acids

Details Nucleic acid-like structures II. Polynucleotide analogues as possible primitive precursors of nucleic acids Nucleic acid-like structures II. Polynucleotide analogues as possible primitive precursors of nucleic acids

Sep 1987

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1987orli...17..351s&link_type=abstract

Origins of Life and Evolution of the Biosphere, Volume 17, Issue 3-4, pp. 351-357

Computer Science

3

Scientific paper

Activated derivatives of purine-containing deoxynucleoside- diphosphates spontaneously oligomerize to produce pyrophosphate- linked oligodeoxynucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors. The efficiency of oligomerization (ImpdGpIm and ImpdApIm much greater than ImpdIpIm) appears to reflect a combination of stacking forces and the specific geometric orientations of the stacked units. Under favorable conditions, chain lengths greater than 20 have been obtained for oligomers containing pdGp in the absence of a template. In the presence of a complementary template, the activated derivatives of pdGp and pdAp oligomerize much more extensively. An acyclo-analogue of G has also been shown to undergo template-directed oligomerization on poly(C). These observations suggest the possibility that primitive information transfer might have evolved in much simpler systems and that this function was taken over by polynucleotides at a later stage in evolution.

Affiliated with

Also associated with

No associations

Rating

Nucleic acid-like structures II. Polynucleotide analogues as possible primitive precursors of nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Nucleic acid-like structures II. Polynucleotide analogues as possible primitive precursors of nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid-like structures II. Polynucleotide analogues as possible primitive precursors of nucleic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-1676991