Nucleic Acid Intercalators Suppress Strand Cyclization in Model Prebiotic Polymerization Reactions

Details Nucleic Acid Intercalators Suppress Strand Cyclization in Model Prebiotic Polymerization Reactions Nucleic Acid Intercalators Suppress Strand Cyclization in Model Prebiotic Polymerization Reactions

Apr 2010

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2010lpico1538.5569h&link_type=abstract

Astrobiology Science Conference 2010: Evolution and Life: Surviving Catastrophes and Extremes on Earth and Beyond, held April 2

Biology

Scientific paper

We show that base pair intercalation by small molecules, which
stabilizes and rigidifies nucleic acid duplexes, reduces strand
cyclization, allowing for chemical ligation of tetranucleotides into
duplex polymers of at least 100 bp in length.

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