Biology – Quantitative Biology – Genomics
Scientific paper
2007-03-29
Biology
Quantitative Biology
Genomics
15 pages, 5 figures
Scientific paper
Transcription regulation is largely governed by the profile and the dynamics of transcription factors' binding to DNA. Stochastic effects are intrinsic to this dynamics and the binding to functional sites must be controled with a certain specificity for living organisms to be able to elicit specific cellular responses. Specificity stems here from the interplay between binding affinity and cellular abundancy of transcription factor proteins and the binding of such proteins to DNA is thus controlled by their chemical potential. We combine large-scale protein abundance data in the budding yeast with binding affinities for all transcription factors with known DNA binding site sequences to assess the behavior of their chemical potentials. A sizable fraction of transcription factors is apparently bound non-specifically to DNA and the observed abundances are marginally sufficient to ensure high occupations of the functional sites. We argue that a biological cause of this feature is related to its noise-filtering consequences: abundances below physiological levels do not yield significant binding of functional targets and mis-expressions of regulated genes are thus tamed.
Aurell Erik
d'Hérouël Aymeric Fouquier
Malmnas Claes
Vergassola Massimo
No associations
LandOfFree
Noise-filtering features of transcription regulation in the yeast S. cerevisiae does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Noise-filtering features of transcription regulation in the yeast S. cerevisiae, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Noise-filtering features of transcription regulation in the yeast S. cerevisiae will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-711380