Neuronal synchrony during anaesthesia - A thalamocortical model

Details Neuronal synchrony during anaesthesia - A thalamocortical model Neuronal synchrony during anaesthesia - A thalamocortical model

2008-10-29

arxiv.org/abs/0810.5198v1

Biophys. J., 95(6), 2722-2727, 2008

Biology

Quantitative Biology

Neurons and Cognition

18 pages, 3 figures

Scientific paper

10.1529/biophysj.108.134635

There is growing evidence in favour of the temporal-coding hypothesis that temporal correlation of neuronal discharges may serve to bind distributed neuronal activity into unique representations and, in particular, that $\theta$ (3.5-7.5 Hz) and $\delta$ ($0.5<$3.5 Hz) oscillations facilitate information coding. The $\theta$ and $\delta$ rhythms are shown to be involved in various sleep stages, and during an{\ae}sthesia, and they undergo changes with the depth of an{\ae}sthesia. We introduce a thalamocortical model of interacting neuronal ensembles to describe phase relationships between $\theta$ and $\delta$ oscillations, especially during deep and light an{\ae}sthesia. Asymmetric and long range interactions among the thalamocortical neuronal oscillators are taken into account. The model results are compared with the experimental observations of Musizza et al. {\it J. Physiol. (London)} 2007 580:315-326. The $\delta$ and $\theta$ activities are found to be separately generated and are governed by the thalamus and cortex respectively. Changes in the degree of intra--ensemble and inter--ensemble synchrony imply that the neuronal ensembles inhibit information coding during deep an{\ae}sthesia and facilitate it during light an{\ae}sthesia.

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