Mutation induction in yeast by very heavy ions

Details Mutation induction in yeast by very heavy ions Mutation induction in yeast by very heavy ions

Oct 1994

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1994adspr..14..331k&link_type=abstract

Advances in Space Research, Volume 14, Issue 10, p. 331-338.

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Resistance to canavanine was studied in haploid yeast after exposure to heavy ions (argon to uranium) of energies between 1 and 10 MeV/u covering a LET-range up to about 10000 keV/μm. Mutations were found in all instances but the induction cross sections increased with ion energy. This is taken to mean that the contribution of penumbra electrons plays an important role. The probability to recover surviving mutants is highest if the cell is not directly hit by the particle. The experiments demonstrate that the geometrical dimensions of the target cell nucleus as well as its sensitivity in terms of survival have a critical influence on mutation induction with very heavy ions.

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