Multiprotein DNA looping

Details Multiprotein DNA looping Multiprotein DNA looping

2006-03-17

arxiv.org/abs/q-bio/0603020v2

Phys. Rev. Lett. 96, 238103 (2006)

Biology

Quantitative Biology

Subcellular Processes

11 pages, 4 figures

Scientific paper

10.1103/PhysRevLett.96.238103

DNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switch-like transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance.

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