Statistics – Methodology
Scientific paper
2008-05-15
IMS Collections 2008, Vol. 1, 243-256
Statistics
Methodology
Published in at http://dx.doi.org/10.1214/193940307000000176 the IMS Collections (http://www.imstat.org/publications/imscollec
Scientific paper
10.1214/193940307000000176
While multiple testing procedures have been the focus of much statistical research, an important facet of the problem is how to deal with possible confounding. Procedures have been developed by authors in genetics and statistics. In this chapter, we relate these proposals. We propose two new multiple testing approaches within this framework. The first combines sensitivity analysis methods with false discovery rate estimation procedures. The second involves construction of shrinkage estimators that utilize the mixture model for multiple testing. The procedures are illustrated with applications to a gene expression profiling experiment in prostate cancer.
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