Statistics – Machine Learning
Scientific paper
2009-12-16
Statistics
Machine Learning
9 pages, 4 figures
Scientific paper
We extend multi-way, multivariate ANOVA-type analysis to cases where one covariate is the view, with features of each view coming from different, high-dimensional domains. The different views are assumed to be connected by having paired samples; this is a common setup in recent bioinformatics experiments, of which we analyze metabolite profiles in different conditions (disease vs. control and treatment vs. untreated) in different tissues (views). We introduce a multi-way latent variable model for this new task, by extending the generative model of Bayesian canonical correlation analysis (CCA) both to take multi-way covariate information into account as population priors, and by reducing the dimensionality by an integrated factor analysis that assumes the metabolites to come in correlated groups.
Huopaniemi Ilkka
Kaski Samuel
Nikkilä Janne
Orešič Matej
Suvitaival Tommi
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