mRNA diffusion explains protein gradients in \textit{Drosophila} early development

Details mRNA diffusion explains protein gradients in \textit{Drosophila} early development mRNA diffusion explains protein gradients in \textit{Drosophila} early development

2009-09-23

arxiv.org/abs/0909.4239v1

Biology

Quantitative Biology

Quantitative Methods

14 pages, 2 figures

Scientific paper

We propose a new model describing the production and the establishment of the stable gradient of the Bicoid protein along the antero-posterior axis of the embryo of \textit{Drosophila}. In this model, we consider that \textit{bicoid} mRNA diffuses along the antero-posterior axis of the embryo and the protein is produced in the ribosomes localized near the syncytial nuclei. Bicoid protein stays localized near the syncytial nuclei as observed in experiments. We calibrate the parameters of the mathematical model with experimental data taken during the cleavage stages 11 to 14 of the developing embryo of \textit{Drosophila}. We obtain good agreement between the experimental and the model gradients, with relative errors in the range 5-8%. The inferred diffusion coefficient of \textit{bicoid} mRNA is in the range 4.6\times 10^{-12}-1.5\times 10^{-11}m^2s^{-1}, in agreement with the theoretical predictions and experimental measurements for the diffusion of macromolecules in the cytoplasm. We show that the model based on the mRNA diffusion hypothesis is consistent with the known observational data, supporting the recent experimental findings of the gradient of \textit{bicoid} mRNA in \textit{Drosophila} [Spirov et al. (2009) Development 136:605-614].

Affiliated with

Also associated with

No associations

Rating

mRNA diffusion explains protein gradients in \textit{Drosophila} early development does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with mRNA diffusion explains protein gradients in \textit{Drosophila} early development, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and mRNA diffusion explains protein gradients in \textit{Drosophila} early development will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-182158