Mathematics – Logic
Scientific paper
Oct 1994
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1994adspr..14..161n&link_type=abstract
Advances in Space Research, Volume 14, Issue 10, p. 161-180.
Mathematics
Logic
1
Scientific paper
Estimation of exposure due to environmental and other sources of radiations of high-LET and low-LET is of interest in radiobiology and radiation protection for risk assessment. To account for the differences in effectiveness of different types of radiations various parameters have been used. However, the relative inadequacy of the commonly used parameters, including dose, fluence, linear energy transfer, lineal energy, specific energy and quality factor, has been made manifest by the biological importance of the microscopic track structure and primary modes of interaction. Monte Carlo track structure simulations have been used to calculate the frequency of energy deposition by radiations of high- and low-LET in target sizes similar to DNA and higher order genomic structure. Tracks of monoenergenic heavy ions and electrons were constructed by following the molecular interaction-by-interaction histories of the particles down to 10 eV. Subsequently, geometrical models of these assumed biological targets were randomly exposed to the radiation tracks and the frequency of energy depositions obtained were normalized to unit dose in unit density liquid water (103 kg m-3). From these data and a more sophisticated model of the DNA, absolute yields of both single-and double-strand breaks expressed in number of breaks per dalton per Gray were obtained and compared with the measured yields. The relative biological effectiveness (RBE) for energy depositions on cylindrical targets has been calculated using 100 keV electrons at the reference radiation assuming the electron track-ends contribution is similar to that in 250 kV X-ray or Co60 λ-ray irradiations.
Charlton Dave E.
Goodhead D. T.
Nikjoo H.
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