Modulation of Base Specific Mutation and Recombination Rates Enables Functional Adaptation within the Context of the Genetic Code

Details Modulation of Base Specific Mutation and Recombination Rates Enables Functional Adaptation within the Context of the Genetic Code Modulation of Base Specific Mutation and Recombination Rates Enables Functional Adaptation within the Context of the Genetic Code

2004-04-20

arxiv.org/abs/q-bio/0404022v1

Biology

Quantitative Biology

Genomics

30 pages; 6 figures; 6 tables; to appear in J. Mol. Evol

Scientific paper

The persistence of life requires populations to adapt at a rate commensurate with the dynamics of their environment. Successful populations that inhabit highly variable environments have evolved mechanisms to increase the likelihood of successful adaptation. We introduce a $64 \times 64$ matrix to quantify base-specific mutation potential, analyzing four different replicative systems, error-prone PCR, mouse antibodies, a nematode, and Drosophila. Mutational tendencies are correlated with the structural evolution of proteins. In systems under strong selective pressure, mutational biases are shown to favor the adaptive search of space, either by base mutation or by recombination. Such adaptability is discussed within the context of the genetic code at the levels of replication and codon usage.

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