Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery

Details Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery

2011-09-07

arxiv.org/abs/1109.1495v1

Biology

Quantitative Biology

Subcellular Processes

31 pages, 11 figures. To appear on SIAM

Scientific paper

Gene delivery of nucleic acid to the cell nucleus is a fundamental step in gene therapy. In this review of modeling drug and gene delivery, we focus on the particular stage of plasmid DNA or virus cytoplasmic trafficking. A challenging problem is to quantify the success of this limiting stage. We present some models and simulations of plasmid trafficking and of the limiting phase of DNA-polycation escape from an endosome and discuss virus cytoplasmic trafficking. The models can be used to assess the success of viral escape from endosomes, to quantify the early step of viral-cell infection, and to propose new simulation tools for designing new hybrid-viruses as synthetic vectors.

Affiliated with

Also associated with

No associations

Rating

Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-306591