Modeling stochastic Ca$^{2+}$ release from a cluster of IP$_3$-sensitive receptors

Biology – Quantitative Biology – Subcellular Processes

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

25 pages 10 figures, revised version

Scientific paper

We focused our attention on Ca$^{2+}$ release from the endoplasmic reticulum through a cluster of inositol 1,4,5-trisphosphate (IP$_3$) receptor channels. The random opening and closing of these receptors introduce stochastic effects that have been observed experimentally. Here, we present a stochastic version of Othmer-Tang model for IP$_3$ receptor clusters. We address the average behavior of the channels in response to IP$_3$ stimuli. We found, by stochastic simulation, that the shape of the receptor response to IP$_3$ (fraction of open channels versus [IP$_3$]), is affected by the cytosolic Ca$^{2+}$ level. We also study several aspects of the stochastic properties of Ca${2+}$ release and we compare with experimental observations.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Modeling stochastic Ca$^{2+}$ release from a cluster of IP$_3$-sensitive receptors does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Modeling stochastic Ca$^{2+}$ release from a cluster of IP$_3$-sensitive receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modeling stochastic Ca$^{2+}$ release from a cluster of IP$_3$-sensitive receptors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-267257

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.