Biology – Quantitative Biology – Subcellular Processes
Scientific paper
2007-06-15
Phys. Biol. 4 (2007) 145-153.
Biology
Quantitative Biology
Subcellular Processes
17 pages, including 6 figures. Typo in captions of fig.2,5 corrected. Version which appears in Physical Biology
Scientific paper
10.1088/1478-3975/4/3/001
Ongoing sub-cellular oscillation of Min proteins is required to block minicelling in E. coli. Experimentally, Min oscillations are seen in newly divided cells and no minicells are produced. In model Min systems many daughter cells do not oscillate following septation because of unequal partitioning of Min proteins between the daughter cells. Using the 3D model of Huang et al., we investigate the septation process in detail to determine the cause of the asymmetric partitioning of Min proteins between daughter cells. We find that this partitioning problem arises at certain phases of the MinD and MinE oscillations with respect to septal closure and it persists independently of parameter variation. At most 85% of the daughter cells exhibit Min oscillation following septation. Enhanced MinD binding at the static polar and dynamic septal regions, consistent with cardiolipin domains, does not substantially increase this fraction of oscillating daughters. We believe that this problem will be shared among all existing Min models and discuss possible biological mechanisms that may minimize partitioning errors of Min proteins following septation.
Rutenberg Andrew D.
Sengupta Supratim
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