Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2004-10-01
Journal of Computational Neuroscience 17: 347-363 (2004)
Biology
Quantitative Biology
Neurons and Cognition
brain, model, neural development, cortical area patterning, signaling molecules
Scientific paper
The mammalian cortex is divided into architectonic and functionally distinct areas. There is growing experimental evidence that their emergence and development is controlled by both epigenetic and genetic factors. The latter were recently implicated as dominating the early cortical area specification. In this paper, we present a theoretical model that explicitly considers the genetic factors and that is able to explain several sets of experiments on cortical area regulation involving transcription factors Emx2 and Pax6, and fibroblast growth factor FGF8. The model consists of the dynamics of thalamo- cortical connections modulated by signaling molecules that are regulated genetically, and by axonal competition for neocortical space. The model can make predictions and provides a basic mathematical framework for the early development of the thalamo-cortical connections and area patterning that can be further refined as more experimental facts become known.
Ermentrout Bard G.
Karbowski Jan
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