Model of actin-based motility based on transient attachment

Details Model of actin-based motility based on transient attachment Model of actin-based motility based on transient attachment

Mar 2002

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2002aps..marp33246b&link_type=abstract

American Physical Society, Annual APS March Meeting, March 18 - 22, 2002 Indiana Convention Center; Indianapolis, Indiana Meetin

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Scientific paper

Motivated by recent studies of motions of Listeria and ActA or WASP-coated beads in cell extracts, we propose a transient attachment model, in which forward motions may be coupled to sideways drifting and rotation. In contrast to thermal rachet models, this model is based on filament pinning and depinning. Actin filaments growing at an angle to an obstacle's surface, and pinned to specific proteins on that surface, may randomly depin, grow by the addition of a monomer subunit or two, and then repin to either the same site or another. Repinning to the same site can result in relative lateral motion between the obstacle and the filament network. Such motion can encourage the growth of other filaments pointing in the same direction (relative to normal) and discourage the growth of others. In this way, an initial asymmetry in growth angle can be self-sustaining. Using this concept of spontaneous symmetry breaking applied to actin filaments of various orientations pushing an obstacle, we analyze the experimentally observed turning of comet tails, as well as rotation of a dead bacterium as it is propelled forward by its comet tail. To help illustrate our model, the behavior of the model is explored through numerical simulations.

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