Microtubule Length-Regulation by Molecular Motors

Details Microtubule Length-Regulation by Molecular Motors Microtubule Length-Regulation by Molecular Motors

2012-04-25

arxiv.org/abs/1204.5655v1

Biology

Quantitative Biology

Subcellular Processes

7 pages (5 p. letter, 3 p. supplementary information), 4 figures (3 f. letter, 1 f. supplementary information)

Scientific paper

Length-regulation of microtubules (MTs) is essential for many cellular processes. Molecular motors like kinesin 8, which move along MTs and also act as depolymerases, are known as key players in MT dynamics. However, the regulatory mechanisms of length control remain elusive. Here, we investigate a stochastic model accounting for the interplay between polymerization kinetics and motor-induced depolymerization. We determine the dependence of MT length and variance on rate constants and motor concentration. Moreover, our analyses reveal how collective phenomena lead to a well-defined MT length.

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