Biology – Quantitative Biology – Quantitative Methods
Scientific paper
2006-06-16
Biology
Quantitative Biology
Quantitative Methods
Changed content and notation
Scientific paper
10.1088/1367-2630/8/8/148
In this paper, we propose a mean-field model which attempts to bridge the gap between random Boolean networks and more realistic stochastic modeling of genetic regulatory networks. The main idea of the model is to replace all regulatory interactions to any one gene with an average or effective interaction, which takes into account the repression and activation mechanisms. We find that depending on the set of regulatory parameters, the model exhibits rich nonlinear dynamics. The model also provides quantitative support to the earlier qualitative results obtained for random Boolean networks.
Andrecut Mircea
Kauffman Stuart A.
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