Mass spectrometry proteomic diagnosis: enacting the validation paradigm

Details Mass spectrometry proteomic diagnosis: enacting the validation paradigm Mass spectrometry proteomic diagnosis: enacting the validation paradigm

2005-10-10

arxiv.org/abs/math/0510188v1

Mathematics

Statistics Theory

21 pages, 4 figures, see http://clinicalresearch.nl/personalpage/ for updated info or contact information

Scientific paper

This paper presents an approach to the evaluation and validation of mass spectrometry data for construction of an `early warning' diagnostic procedure. We describe implementation of a designed experiment and place emphasis on the consistent and correct use of validation based evaluation - which is a key requirement to achieve unbiased assessment of the ability of mass spectrometry data for diagnosis in this setting. Strict adherence to validation as a scientific principle will however typically imply that the analyst must make choices. Like all choices in statistical analysis, validation comes at a cost! We present a detailed and extensive discussion of the issues involved and propose that much greater emphasis and requirement for validation would enter clinical proteomic science.

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