Macroscopic Kinetic Effect of Cell-to-Cell Variation in Biochemical Reactions

Details Macroscopic Kinetic Effect of Cell-to-Cell Variation in Biochemical Reactions Macroscopic Kinetic Effect of Cell-to-Cell Variation in Biochemical Reactions

2009-12-19

arxiv.org/abs/0912.3941v2

Phys. Rev. Lett. 104, 148103 (2010)

Biology

Quantitative Biology

Subcellular Processes

Scientific paper

10.1103/PhysRevLett.104.148103

Genetically identical cells under the same environmental conditions can show strong variations in protein copy numbers due to inherently stochastic events in individual cells. We here develop a theoretical framework to address how variations in enzyme abundance affect the collective kinetics of metabolic reactions observed within a population of cells. Kinetic parameters measured at the cell population level are shown to be systematically deviated from those of single cells, even within populations of homogeneous parameters. Because of these considerations, Michaelis-Menten kinetics can even be inappropriate to apply at the population level. Our findings elucidate a novel origin of discrepancy between in vivo and in vitro kinetics, and offer potential utility for analysis of single-cell metabolomic data.

Affiliated with

Also associated with

No associations

Rating

Macroscopic Kinetic Effect of Cell-to-Cell Variation in Biochemical Reactions does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Macroscopic Kinetic Effect of Cell-to-Cell Variation in Biochemical Reactions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macroscopic Kinetic Effect of Cell-to-Cell Variation in Biochemical Reactions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-62034