Biology – Quantitative Biology – Subcellular Processes
Scientific paper
2007-01-26
Phys. Rev. E 76, 051920 (2007)
Biology
Quantitative Biology
Subcellular Processes
4 pages, 4 figures
Scientific paper
10.1103/PhysRevE.76.051920
Calcium (Ca) plays an important role in regulating various cellular processes. In a variety of cell types, Ca signaling occurs within microdomains where channels deliver localized pulses of Ca which activate a nearby collection of Ca-sensitive receptors. The small number of channels involved ensures that the signaling process is stochastic. The aggregate response of several thousand of these microdomains yields a whole-cell response which dictates the cell behavior. Here, we study analytically the statistical properties of a population of these microdomains in response to a trigger signal. We apply these results to understand the relationship between Ca influx and Ca release in cardiac cells. In this context, we use a first passage time approach to show analytically how Ca release in the whole cell depends on the single channel kinetics of Ca channels and the properties of microdomains. Using these results, we explain the underlying mechanism for the graded relationship between Ca influx and Ca release in cardiac cells.
Das Kunal K.
Garfinkel Alan
Rovetti Robert
Shiferaw Yohannes
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