Lung Surface Area Measurements Using Polarized Xenon NMR

Details Lung Surface Area Measurements Using Polarized Xenon NMR Lung Surface Area Measurements Using Polarized Xenon NMR

Mar 1999

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1999aps..cntxc3205h&link_type=abstract

American Physical Society, Centennial Meeting, March 20-26, 1999, Atlanta, GA, Bulletin of the American Physical Society, Vol.

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Scientific paper

We are using laser-polarized xenon NMR to image the exchange of xenon from the lung gas space into solution in the alveolar tissue lining. The short-time rate of such xenon exchange depends on the surface area of the interface between the dissolved and gas phases. Hence xenon interphase exchange NMR will provide a non-invasive means to map the surface area of the lung. Since the function of the lung is to exchange gases between the bloodstream and the air, and the effectiveness of this gas exchange depends critically on the surface area of contact between blood-filled lung tissue and gas, our measurements will comprise imaging of lung function. This technique could be a powerful new tool for disease diagnosis and fundamental physiological research.

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