Biology – Quantitative Biology – Tissues and Organs
Scientific paper
2008-05-02
Biology
Quantitative Biology
Tissues and Organs
17 pages, 7 figures, as accepted to Biophysical Journal 2008/11/25
Scientific paper
10.1016/j.bpj.2008.11.031
We aim to assess the effectiveness of feedback controlled resonant drift pacing as a method for low energy defibrillation. Antitachycardia pacing is the only low energy defibrillation approach to have gained clinical significance, but it is still suboptimal. Low energy defibrillation would avoid adverse side effects associated with high voltage shocks and allow the application of ICD therapy where it is not tolerated today. We present results of computer simulations of a bidomain model of cardiac tissue with human atrial ionic kinetics. Re-entry was initiated and low energy shocks were applied with the same period as the re-entry, using feedback to maintain resonance. We demonstrate that such stimulation can move the core of re-entrant patterns, in the direction depending on location of electrodes and a time delay in the feedback. Termination of re-entry is achieved with shock strength one order of magnitude weaker than in conventional single-shock defibrillation. We conclude that resonant drift pacing can terminate re-entry at a fraction of the shock strength currently used for defibrillation and can potentially work where antitachycardia pacing fails, due to the feedback mechanisms. Success depends on a number of details which these numerical simulations have uncovered. \emph{Keywords} Re-entry; Bidomain model; Resonant drift; ICD; Defibrillation; Antitachycardia pacing; Feedback.
Biktashev Vadim N.
Biktasheva Irina V.
Morgan Steven W.
Plank G.
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