Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks?

Details Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks? Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks?

2006-06-22

arxiv.org/abs/q-bio/0606029v1

Biology

Quantitative Biology

Genomics

15 pages, 2 figures

Scientific paper

In protein-protein interaction networks certain topological properties appear to be recurrent: networks maps are considered scale-free. It is possible that this topology is reflected in the protein structure. In this paper we investigate the role of protein disorder in the network topology. We find that the disorder of a protein (or of its neighbors) is independent of its number of protein-protein interactions. This result suggests that protein disorder does not play a role in the scale-free architecture of protein networks.

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