Biology – Quantitative Biology – Tissues and Organs
Scientific paper
2011-05-25
Bone 50, 378-389 (2012)
Biology
Quantitative Biology
Tissues and Organs
17 pages, 11 figures, 1 table. Revised version: paper entirely rewritten for a more biology-oriented readership. Technical poi
Scientific paper
10.1016/j.bone.2011.10.021
In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU). Our model takes into account the interaction of osteoclasts with the bone matrix, the interaction of osteoclasts with each other, the generation of osteoclasts from a growing blood vessel, and the renewal of osteoclast nuclei by cell fusion. All these features are shown to strongly influence the geometrical properties of the developing resorption cavity including its size, shape and progression rate, and are also shown to influence the distribution, resorption pattern and trajectories of individual osteoclasts within the BMU. We demonstrate that for certain parameter combinations, resorption cavity shapes can be recovered from the computational model that closely resemble resorption cavity shapes observed from microCT imaging of human cortical bone.
Buenzli Pascal R.
Cummings Peter T.
Jeon Jeongho
Pivonka Peter
Smith David W.
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