Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model

Biology – Quantitative Biology – Tissues and Organs

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

17 pages, 11 figures, 1 table. Revised version: paper entirely rewritten for a more biology-oriented readership. Technical poi

Scientific paper

10.1016/j.bone.2011.10.021

In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU). Our model takes into account the interaction of osteoclasts with the bone matrix, the interaction of osteoclasts with each other, the generation of osteoclasts from a growing blood vessel, and the renewal of osteoclast nuclei by cell fusion. All these features are shown to strongly influence the geometrical properties of the developing resorption cavity including its size, shape and progression rate, and are also shown to influence the distribution, resorption pattern and trajectories of individual osteoclasts within the BMU. We demonstrate that for certain parameter combinations, resorption cavity shapes can be recovered from the computational model that closely resemble resorption cavity shapes observed from microCT imaging of human cortical bone.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-191873

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.