Invertibility of the TKF model of sequence evolution

Details Invertibility of the TKF model of sequence evolution Invertibility of the TKF model of sequence evolution

2006-08-08

arxiv.org/abs/q-bio/0608017v1

Mathematical Biosciences 200, no. 1 (2006) 58-75

Biology

Quantitative Biology

Genomics

23 pages

Scientific paper

We consider character sequences evolving on a phylogenetic tree under the TKF91 model. We show that as the sequence lengths tend to infinity the the topology of the phylogenetic tree and the edge lengths are determined by any one of (a) the alignment of sequences (b) the collection of sequence lengths. We also show that the probability of any homology structure on a collection of sequences related by a TKF91 process on a tree is independent of the root location. Keywords: phylogenetics, DNA sequence evolution models, identifiability, alignment

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