Interchromatidal central ridge and transversal symmetry in early metaphasic human chromosome one

Details Interchromatidal central ridge and transversal symmetry in early metaphasic human chromosome one Interchromatidal central ridge and transversal symmetry in early metaphasic human chromosome one

2008-03-06

arxiv.org/abs/0803.0964v1

Biology

Quantitative Biology

Genomics

Scientific paper

The topographic structure of Giemsa banded (G-banded) early metaphase human chromosomes adsorbed on glass was analyzed by atomic force microscope using amplitude modulation mode [AM-AFM]. Longitudinal height measurements for early metaphasic human chromosomes showed a central ridge that was further characterized by transversal height measurements. The heterochromatic regions displayed a high level of transversal symmetry, while the euchromatic ones presented several peaks across the transversal height measurements. We suggest that this central ridge and symmetry patterns point out a transitional arrangement of the early metaphase chromosome and support evidence for interchromatidal interactions prior to disjunction.

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