Biology – Quantitative Biology – Other Quantitative Biology
Scientific paper
2007-12-17
Progress in Biophysics and Molecular Biology, 2009
Biology
Quantitative Biology
Other Quantitative Biology
Scientific paper
10.1016/j.pbiomolbio.2009.06.003
Noise in gene expression, either due to inherent stochasticity or to varying inter- and intracellular environment, can generate significant cell-to-cell variability of protein levels in clonal populations. We present a theoretical framework, based on stochastic processes, to quantify the different sources of gene expression noise taking cell division explicitly into account. Analytical, time-dependent solutions for the noise contributions arising from the major steps involved in protein synthesis are derived. The analysis shows that the induction level of the activator or transcription factor is crucial for the characteristic signature of the dominant source of gene expression noise and thus bridges the gap between seemingly contradictory experimental results. Furthermore, on the basis of experimentally measured cell distributions, our simulations suggest that transcription factor binding and promoter activation can be modelled independently of each other with sufficient accuracy.
Fleck Christian
Kollmann Markus
Rausenberger Julia
Timmer Jens
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