Immunochemical Proof that a Novel Rearranging Gene Encodes the T Cell Receptor δ Subunit

Details Immunochemical Proof that a Novel Rearranging Gene Encodes the T Cell Receptor δ Subunit Immunochemical Proof that a Novel Rearranging Gene Encodes the T Cell Receptor δ Subunit

Oct 1987

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1987sci...238..682b&link_type=abstract

Science, Volume 238, Issue 4827, pp. 682-684

Computer Science

12

Scientific paper

The T cell receptor (TCR) δ protein is expressed as part of a heterodimer with TCR γ , in association with the CD3 polypeptides on a subset of functional peripheral blood T lymphocytes, thymocytes, and certain leukemic T cell lines. A monoclonal antibody directed against TCR δ was produced that binds specifically to the surface of several TCR γ δ cell lines and immunoprecipitates the TCR γ δ as a heterodimer from Triton X-100 detergent lysates and also immunoprecipitates the TCR δ subunit alone after chain separation. A candidate human TCR δ complementary DNA clone (IDP2 O-240/38), reported in a companion paper, was isolated by the subtractive library approach from a TCR γ δ cell line. This complementary DNA clone was used to direct the synthesis of a polypeptide that is specifically recognized by the monoclonal antibody to TCR δ . This complementary DNA clone thus corresponds to the gene that encodes the TCR δ subunit.

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