Computer Science
Scientific paper
Oct 2004
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2004spie.5578..109y&link_type=abstract
Photonics North 2004: Optical Components and Devices. Edited by Armitage, John C.; Fafard, Simon; Lessard, Roger A.; Lampropoul
Computer Science
Scientific paper
A DNA sensor using a long-period grating (LPG) is proposed for sensitive detection of interaction between the single strand DNA (ssDNA) and its target. The ssDNA can be immobilized on the surface of the LPG, and detection of the specific interaction between the ssDNA and its target is monitored optically. This sensor operates on the evanescent field interacting with the ssDNA immobilized over the grating region. The reaction between the ssDNA and its target alter the effective refractive index of the cladding mode and thus change the LPG transmission spectrum, which can be monitored in real time. This technology should permit a label-free detection of DNA/DNA, DNA/proteins or DNA/small molecules interactions. In this paper, for the first time, dependence of the LPG transmission spectrum on the characteristic of the LPG and the property of the immobilized ssDNA are studied both theoretically and experimentally. Experimental demonstration of the immobilization of ssDNA on LPG and its real-time effect on the transmission spectrum are reported.
Li Yingfu
Nutiu Razvan
Xu Chang-Qing
Yang Jian
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