Biology – Quantitative Biology – Quantitative Methods
Scientific paper
2007-10-15
Biology
Quantitative Biology
Quantitative Methods
Scientific paper
Environment specific substitution tables have been used effectively for distinguishing structural and functional constraints on proteins and thereby identify their active sites (Chelliah et al. (2004)). This work explores whether a similar approach can be used to identify specificity determining residues (SDRs) responsible for cofactor dependence, substrate specificity or subtle catalytic variations. We combine structure-sequence information and functional annotation from various data sources to create structural alignments for homologous enzymes and functional partitions therein. We develop a scoring procedure to predict SDRs and assess their accuracy using information from bound specific ligands and published literature.
Blundell Tom
Gore Swanand
No associations
LandOfFree
Identification of specificity determining residues in enzymes using environment specific substitution tables does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Identification of specificity determining residues in enzymes using environment specific substitution tables, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of specificity determining residues in enzymes using environment specific substitution tables will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-126913