Identification of 11 potential malaria vaccine candidates using Bioinformatics

Details Identification of 11 potential malaria vaccine candidates using Bioinformatics Identification of 11 potential malaria vaccine candidates using Bioinformatics

2010-09-29

arxiv.org/abs/1009.5956v1

VacciMonitor (2010), volumen 19(3), pp. 15-19

Biology

Quantitative Biology

Genomics

5 pages

Scientific paper

In this paper, we suggested eleven protein targets to be used as possible vaccines against Plasmodium falciparum causative agent of almost two to three million deaths per year. A comprehensive analysis of protein target have been selected from the small experimental fragment of antigen in the P. falciparum genome, all of them common to the four stages of the parasite life cycle (i.e., sporozoites, merozoites, trophozoites and gametocytes). The potential vaccine candidates should be analyzed in silico technique using various bioinformatics tools. Finally, the possible protein target according to PlasmoDB gene ID are PFC0975c, PFE0660c, PF08_0071, PF10_0084, PFI0180w, MAL13P1.56, PF14_0192, PF13_0141, PF14_0425, PF13_0322, y PF14_0598.

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