Identification and Query of Activated Gene Pathways in Disease Progression

Details Identification and Query of Activated Gene Pathways in Disease Progression Identification and Query of Activated Gene Pathways in Disease Progression

2009-05-19

arxiv.org/abs/0905.3198v2

Biology

Quantitative Biology

Genomics

Scientific paper

Disease occurs due to aberrant expression of genes and modulation of the biological pathways along which they lie. Inference of activated gene pathways, using gene expression data during disease progression, is an important problem. In this work, we have developed a generalizable framework for the identification of interacting pathways while incorporating biological realism, using functional data analysis and manifold embedding techniques. Additionally, we have also developed a new method to query for the differential co-ordinated activity of any desired pathway during disease progression. The methods developed in this work can be generalized to any conditions of interest.

Affiliated with

Also associated with

No associations

Rating

Identification and Query of Activated Gene Pathways in Disease Progression does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Identification and Query of Activated Gene Pathways in Disease Progression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification and Query of Activated Gene Pathways in Disease Progression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-242025