Hysteresis in the cell response to time-dependent substrate stiffness

Details Hysteresis in the cell response to time-dependent substrate stiffness Hysteresis in the cell response to time-dependent substrate stiffness

2010-07-07

arxiv.org/abs/1007.1092v1

Biophysical Journal, Volume 99, Issue 1, L10-L12, 7 July 2010

Biology

Quantitative Biology

Cell Behavior

Revtex, 4 PDF figures

Scientific paper

10.1016/j.bpj.2010.04.008

Mechanical cues like the rigidity of the substrate are main determinants for the decision making of adherent cells. Here we use a mechano-chemical model to predict the cellular response to varying substrate stiffness. The model equations combine the mechanics of contractile actin filament bundles with a model for the Rho-signaling pathway triggered by forces at cell-matrix contacts. A bifurcation analysis of cellular contractility as a function of substrate stiffness reveals a bistable response, thus defining a lower threshold of stiffness, below which cells are not able to build up contractile forces, and an upper threshold of stiffness, above which cells are always in a strongly contracted state. Using the full dynamical model, we predict that rate-dependent hysteresis will occur in the cellular traction forces when cells are exposed to substrates of time-dependent stiffness.

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