How shall we use the proteomics toolbox for biomarker discovery?

Details How shall we use the proteomics toolbox for biomarker discovery? How shall we use the proteomics toolbox for biomarker discovery?

2008-07-08

arxiv.org/abs/0807.1206v1

Journal of Proteome Research 6, 9 (2007) 3371-6

Biology

Quantitative Biology

Genomics

Scientific paper

10.1021/pr0702060

Biomarker discovery for clinical purposes is one of the major areas in which proteomics is used. However, despite considerable effort, the successes have been relatively scarce. In this perspective paper, we try to highlight and analyze the main causes for this limited success, and to suggest alternate strategies, which will avoid them, without eluding the foreseeable weak points of these strategies. Two major strategies are analyzed, namely, the switch from body fluids to cell and tissues for the initial biomarker discovery step or, if body fluids must be analyzed, the implementation of highly selective protein selection strategies.

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